学历：
福州大学理学学士，物理化学专业
中国科学院福建物质结构研究所理学博士，物理化学专业
研究方向：
磁共振成像、磁共振波谱、图像与信号处理、深度学习
团队主页: smri.xmu.edu.cn
主讲课程：
文献信息检索与科技写作（本科生课）
核磁共振基础（研究生课）
成果奖励：
[1] 延根，陈忠，蔡淑惠，杨永贵，毛雨萌，王倩琪，翟慧歌. 磁共振一站式成像技术在直肠癌新辅助化疗诊疗中的转化应用. 厦门市科学技术进步奖三等奖，2024.
[2] 延根，陈忠，任克，林雁勤，蔡淑惠，杨永贵，石大发. 代谢物成像磁共振技术在神经精神类疾病的临床转化应用. 厦门市科学技术进步奖三等奖，2022.
[3] 陈忠，郭岗，黄玉清，蔡淑惠，高锦豪. 磁共振分子影像新技术及其在医学诊断中应用. 福建省科技进步奖三等奖，2018.
[4] 陈忠，蔡淑惠，杨天和，郭岗，高锦豪，林建忠，黄玉清，朱柳红. 磁共振分子影像新技术及其在医学诊断中应用. 厦门市科学技术进步奖二等奖，2018.
[5] 郭岗，陈忠，蔡淑惠，杨永贵，蔡聪波. 慢性脑血管功能不全的MRI研究. 福建省科学技术进步奖三等奖，2012.
[6] 郭岗，陈忠，蔡淑惠，杨永贵，蔡聪波，朱柳红. 慢性脑血管功能不全的MRI研究. 厦门市科学技术进步奖三等奖，2012.
[7] 杨天和，陈忠，蔡淑惠，王馨，蔡聪波，林建忠. 医用全身扩散加权成像及其在肿瘤转移灶诊断中的应用. 福建省科学技术进步奖二等奖，2011.
[8] 杨天和，陈忠，蔡淑惠，王馨，蔡聪波，林建忠. 医用全身扩散加权成像及其在肿瘤转移灶诊断中的应用. 厦门市科学技术进步奖一等奖，2010.
[9] 福建省三八红旗手，2010.
[10] 谢狄霖，陈忠，邓思珊，蔡淑惠，陈志伟. 核磁共振光谱技术应用于医药学研究. 福建省科学技术奖三等奖，2008.
[11] 第十四届福建运盛青年科技奖，2007.
[12] 第八届福建青年科技奖，2006.
[13] 教育部新世纪优秀人才，2005.
[14] 陈忠，蔡淑惠，钟健晖，万惠霖. 核磁共振新技术及其在化学和医学成像中的应用. 福建省科学技术奖二等奖，2003
课题项目：
[1] 单扫描高保真重叠回波分离多参数定量磁共振成像新方法，国家自然科学基金面上项目，2024.1-2027.12，主持.
[2] 新型快速高质量重叠回波分离多参数定量磁共振成像方法，广东省自然科学基金面上项目，2024.1-2026.12，主持.
[3] 生物糖脂代谢的强场磁共振检测新技术及应用，国家重点研究计划项目，2023.12-2028.11，课题负责人.
[4] 牙髓及牙周软组织的高场MRI精细成像技术研究及样机研制，国家重点研发计划项目，2022.11-2025.10，任务负责人.
[5] 高保真超快速时空编码核磁共振成像新技术及其应用，国家自然科学基金面上项目，2018.1-2021.12，主持.
[6] 适用于自由呼吸状态下肝癌检查的时空编码磁敏感加权成像新技术开发，福建省科技计划项目，2016.4-2019.3，主持.
[7] 利用时空编码获得不均匀磁场下高质量单扫描MRI图像新方法，国家自然科学基金面上项目，2015.1-2018.12，主持.
[8] 基于内源性分子的高分辨磁共振分子成像新技术，高等学校博士学科点专项科研基金，2014.1-2016.12，主持.
[9] 新型空间编码超快速磁共振成像和定域二维谱方法研究，国家自然科学基金面上项目，2013.1-2016.12，主持.
[10] 强磁场下大型哺乳动物新型磁共振成像技术与方法的开发与应用，国家自然科学基金重点项目子课题，2013.1-2016.12，主持.
[11] 基于远程偶极相互作用的活体生物组织高分辨核磁共振定域谱方法，国家自然科学基金面上项目，2011.1-2013.12，主持.
[12] 活体生物组织高分辨一维和二维磁共振定域谱技术，高等学校博士学科点专项科研基金，2010.1-2012.12，主持.
[13] 基于广义空间编码的不均匀磁场下快速高分辨核磁共振新技术，国家自然科学基金面上项目，2009.1-2011.12，主持.
[14] 基于远程偶极相互作用的磁共振成像新技术，教育部科学技术研究重点项目，2009.1-2010.12，主持.
[15] 不均匀场下快速获取高分辨核磁共振谱的仿真与实现，福建省自然科学基金，2008.5-2010.5，主持.
[16] 核磁共振中分子间分子内多量子相干、混沌效应及其应用，国家自然科学基金面上项目，2006.1-2008.12，主持.
[17] 分子内和分子间多量子相干效应及其应用，教育部新世纪优秀人才支持计划，2006.1-2008.12，主持.
[18] 具有抗糖尿病活性钒化合物的合成与机理研究，教育部留学回国人员基金，2005.1-2006.12，主持.
[19] 具有催化和生物活性过渡金属配合物的合成、反应机理及性质研究，固体表面物理化学国家重点实验室基金，2003.12-2005.11，主持.
[20] NMR中分子间多量子相干物理模型、计算机模拟及其应用，国家自然科学基金青年项目，2002.1-2004.12，主持.
[21] 活性钒化合物的催化和生化作用机理及其反应动力学，福建省自然科学基金，2001.5-2003.4，主持.
[22] 平均键能理论与本征半导体费米能级计算方法的研究，福建省自然科学基金，1997.5-1999.5，主持
代表作：
[1] Wang JC, Chen ZQ, Cai CB, Cai SH*, 2024. Ultrafast diffusion tensor imaging based on deep learning and multi-slice information sharing. Physics in Medicine and Biology, 69:035011.
[2] Li ZY, Wang X, Zhang HY, Yang YJ, Zhang Y, Zhuang YC, Yang QQ, Gao ER, Ren YN, Zhang Y, Cai SH, Chen Z, Cai CB, Dong YB, Bao JF, Cheng JL*, 2024. Positive progesterone receptor expression in meningioma may increase the transverse relaxation: First prospective clinical trial using single-shot ultrafast T2 mapping. Academic Radiology, 31(1):187-198.
[3] Wang JC, Geng WH, Wu J, Kang TS, Wu ZG, Lin JZ, Yang Y, Cai CB, Cai SH*, 2023. Intravoxel incoherent motion magnetic resonance imaging reconstruction from highly under-sampled diffusion-weighted PROPELLER acquisition data via physics-informed residual feedback unrolled network. Physics in Medicine and Biology, 68(17):175022.
[4] Chen H, Chen XR, Lin LJ, Cai SH, Cai CB, Chen Z, Xu JD, Chen L*, 2023. Learned spatiotemporal correlation priors for CEST image denoising using incorporated global-spectral convolution neural network. Magnetic Resonance in Medicine, 90:2071-2088.
[5] Dai LX#, Yang QQ#, Lin JZ, Zhou ZH, Zhang PJ, Cai SH, Chen Z, Wu ZG, Kang TS*, Cai CB*, 2023. Learning from synthetic data for reference-free Nyquist ghost correction and parallel imaging reconstruction of echo planar imaging. Medical Physics, 50:2135-2147.
[6] Yang QQ, Ma LC, Zhou ZH, Bao JF, Yang QZ, Huang HT, Cai SH, He HJ, Chen Z, Zhong JH, Cai CB*, 2023. Rapid high-fidelity T2* mapping using single-shot overlapping-echo acquisition and deep learning reconstruction. Magnetic Resonance in Medicine, 89:2157-2170.
Lin X#, Dai LX#, Yang QQ, Yang QZ, He HJ, Ma LC, Liu JJ, Cheng JL, [7] Cai CB*, Bao JF*, Chen Z, Cai SH, Zhong JH, 2023. Free-breathing and instantaneous abdominal T2 mapping via single-shot multiple overlapping-echo acquisition and deep learning reconstruction. European Radiology, 33:4938-4948.
[8] Wu J#, Kang TS#, Lan XL, Chen XR, Wu ZG, Wang JZ, Lin LJ, Cai CB, Lin JZ, Xin D, Cai SH*, 2023. IMPULSED model based cytological feature estimation with U-Net: application to human brain tumor at 3 T. Magnetic Resonance in Medicine, 89:411-422.
[9] Huang HT, Yang QQ, Wang JC, Zhang PJ, Cai SH, Cai CB*, 2023. High-efficient Bloch simulation of magnetic resonance imaging sequences based on deep learning. Physics in Medicine and Biology, 68(8):085002.
[10] Chen H, Chen XR, Lin LJ, Cai SH, Cai CB, Chen Z, Xu JD, Chen L, 2023. Learned spatiotemporal correlation priors for CEST image denoising using incorporated global-spectral convolution neural network. Magnetic Resonance in Medicine, 90:2071-2088.
[11] Zhan HL, Hao MY, Lin EP, Zheng ZY, Huang CD, Cai SH, Cao SH*, Huang YQ*, Chen Z, 2023. A pure shift-based nuclear magnetic resonance method for in-phase three-dimensional diffusion-ordered spectroscopy. Analytical Chemistry, 95(2):1002-1007.
[12] Li SM#, Kang TS#, Wu J, Chen WK, Lin Q, Wu ZG, Wang JZ, Cai CB, Cai SH*, 2023. Sub-second whole brain T2 mapping via multiband SENSE multiple overlapping-echo detachment imaging and deep learning. Physics in Medicine & Biology, 68:195027.
[13] Ouyang BY, Yang QZ, Wang XY, He HJ, Ma LC, Yang QQ, Zhou ZH, Cai SH*, Chen Z, Wu ZG, Zhong JH*, Cai CB, 2022. single-shot T2 mapping via multi-echo-train multiple overlapping-echo detachment planar imaging and multitask deep learning. Medical Physics, 49:7095-7107.
[14] Wang JC, Yang QQ, Yang QZ, Xu LN, Cai CB*, Cai SH*, 2022. Joint optimization of Cartesian sampling patterns and reconstruction for single-contrast and multi-contrast fast magnetic resonance imaging. Computer Methods and Programs in Biomedicine, 226:107150.
[15] Ma LC#, Wu J#, Yang QQ, Zhou ZH, He HJ, Bao JF, Bao LJ, Wang XY, Zhang PJ, Zhong JH, Cai CB*, Cai SH*, Chen Z*, 2022. Single-shot multi-parametric mapping based on multiple overlapping-echo detachment (MOLED) imaging. NeuroImage, 263:119645.
[16] Li SM, Wu J, Ma LC, Cai SH*, Cai CB, 2022. A simultaneous multi-slice T2 mapping framework based on overlapping-echo detachment planar imaging and deep learning reconstruction. Magnetic Resonance in Medicine, 87:2239-2253.
[17] Shangguan P, Jiang WJ, Wang JC, Wu J, Cai CB, Cai SH*, 2022. Multi-slice compressed sensing MRI reconstruction based on deep fusion connection network. Magnetic Resonance Imaging, 93:115-127.
[18] Yang QQ, Lin YH, Wang JC, Bao JF, Wang XY, Ma LC, Zhou ZH, Yang QZ, Cai SH, He HJ, Cai CB*, Dong JY*, Cheng JL, Chen Z, Zhong JH, 2022. MOdel-based SyntheTic Data-driven Learning (MOST-DL): Application in single-shot T2 mapping with severe head motion using overlapping-echo acquisition. IEEE Transactions on Medical Imaging, 41(11):3167-3181.
[19] Chen XR, Wang W, Huang JP, Wu J, Chen L*, Cai CB, Cai SH, Zhong Chen, 2022. Ultrafast water-fat separation using deep learning-based single-shot MRI. Magnetic Resonance in Medicine, 87:2811-2825.
[20] Zeng HL, Xing Z, Gao FL, Wu ZG, Huang WR, Su Y, Chen Z, Cai SH, Cao DR*, Cai CB*, 2022. A multimodal domain adaptive segmentation framework for IDH genotype prediction. International Journal of Computer Assisted Radiology and Surgery, 17:1923-1931.
[21] Chen L, Cai SH*, van Zijl PCM, Li X*, 2021. Single-step calculation of susceptibility through multiple orientation sampling. NMR in Biomedicine, 34:e4517.
[22] Guo CL, Wu J, Rosenberg JT, Roussel T, Cai SH*, Cai CB, 2020. Fast chemical exchange saturation transfer imaging based on PROPELLER acquisition and deep neural network reconstruction. Magnetic Resonance in Medicine, 84:3192-3205.
[23] Haung JP, Chen L, Chan KWY, Cai CB*, Cai SH*, Chen Z, 2020. Super-resolved water/fat image reconstruction based on single-shot spatiotemporally encoded MRI. Journal of Magnetic Resonance, 314:106736.
[24] Huang YQ, Zhan HL, You XQ, Yang Y, Li C, Cai SH, Chen Z*, 2020. A pure-shift-based NMR method for transverse relaxation measurements on complex samples. IEEE Transactions on Instrumentation and Measurement, 69(1):201-211.
[25] Zhang J#, Wu J#, Chen SJ#, Zhang ZY, Cai SH*, Cai CB*, Chen Z, 2019. Robust single-shot T2 mapping via multiple overlapping-echo acquisition and deep neural network. IEEE Transactions on Medical Imaging, 38(8):1801-1811.
[26] Zhang L#, Chen X#, Lin JZ, Ding XH, Bao LJ, Cai CB*, Li J, Chen Z, Cai SH*, 2019. Fast quantitative susceptibility reconstruction via total field inversion with improved weighted L0 norm approximation. NMR in Biomedicine, 32:e4067.
[27] Tan CH, Huang YQ*, Cai SH*, Chen Z, 2019. High-resolution two-dimensional 1H J-resolved MRS measurements on in vivo samples. Journal of Magnetic Resonance, 300:51-60.
[28] Chen L, Wei ZL, Cai SH*, Li YG, Liu GS, Lu HZ, Weiss RG, van Zijl PCM, Li T, Xu JD*, 2019. High-resolution creatine mapping of mouse brain at 11.7 T using non-steady-state chemical exchange saturation transfer. NMR in Biomedicine, 32:e4168.
[29] Cai JZ, Wu J, Guo CL, Cai SH*, Cai CB*, 2019. Ultrafast multi-slice chemical exchange saturation transfer imaging scheme based on segmented spatiotemporal encoding. Magnetic Resonance Imaging, 60:122-129.
[30] Zhan HL, Lin XQ, Wei ZL, Ye QM, Cai SH, You XQ, Huang YQ*, Chen Z*, 2019. A single-scan inhomogeneity-tolerant NMR method for high-resolution 2D J-resolved spectroscopy. IEEE Transactions on Biomedical Engineering, 66:1559-1566.
[31] Chen L, Wei ZL, Chan KWY, Cai SH, Liu GS, Lu HZ, Wong PC, van Zijl PCM, Li T*, Xu JD*, 2019. Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. NeuroImage, 188:380-390.
[32] Chen L, Hua J, Ross CA, Cai SH, van Zijl PCM, Li X*, 2019. Altered brain iron content and deposition rate in Huntington's disease as indicated by quantitative susceptibility MRI. Journal of Neuroscience Research, 97:467-479.
[33] Wang X*, Chen ZW, Lv YY, Cai SH, Chen Z, 2019. Synthesis, characterization, and NMR study of oxo-centered trinuclear complexes [Fe2IIINiIIO(O2CC2H5)6(py)3]×py and [Fe2IIINiIIO(O2CC2H5)6(H2O)3]×H2O. Journal of Applied Spectroscopy, 86(3):488.
[34] Zhang ZM, Lin CH, Liu HL, Feng JH*, Zheng ZY, Cai SH, 2019. Specific biological responses following dextran-coated ultra-small superparamagnetic particles of iron oxides administration. Nanomedicine, 14(11):1371-1386.
[35] Wang JL, You XQ, Xiao C, Zhang XP, Cai SH, Jiang WL, Guo SS, Cao SH*, Chen Z*, 2019. Small-sized Pt nanoparticles supported on hybrid structures of MoS2 nanoflowers/graphene nanosheets: Highly active composite catalyst toward efficient ethanol oxidation reaction studied by in situ electrochemical NMR spectroscopy. Applied Catalysis B-Environmental, 259:118060.
[36] Cao SH, Li LH, Wei WY, Feng Y, Jiang WL, Wang JL, Zhang XP, Cai SH, Chen Z*, 2019. A label-free and ultrasensitive DNA impedimetric sensor with enzymatic and electrical dual-amplification. Analyst, 144:4175-4179.
[37] Wang JL, Cao XR, Fang L, Ou XQ*, Wong K, Cao SH, Xiao C, Cai SH, Huang YQ, Zhang XP, Chen Z*, 2019. MoS2 nanoflower supported Pt nanoparticle as an efficient electrocatalyst for ethanol oxidation reaction. International Journal of Hydrogen Energy, 44(31):16411-16423.
[38] Chen L, Zheng ZW, Bao LJ, Fang JS, Yang TH, Cai SH*, Cai CB*, 2018. Weighted total variation using split Bregman fast quantitative susceptibility mapping reconstruction method. Chinese Physics B, 27(8):088701.
[39] Liao P, Zhang J, Zeng K, Yang YG, Cai SH*, Guo G, Cai CB*, 2018. Referenceless distortion correction of gradient-echo echo-planar imaging under inhomogeneous magnetic fields based on a deep convolutional neural network. Computers in Biology and Medicine, 100:230-238.
[40] Luo Y, Zhang J, Chen L, Cai SH*, Cai CB*, 2018. Accelerating multi-slice spatiotemporally encoded MRI with simultaneous echo refocusing. Journal of Magnetic Resonance, 296:12-22.
[41] Cai CB, Wang C, Zeng YQ, Cai SH, Liang D, Wu YW, Chen Z*, Ding XH*, Zhong JH, 2018. Single-shot T2 mapping using overlapping-echo detachment planar imaging and a deep convolutional neural network. Magnetic Resonance in Medicine, 80:2202-2214.
[42] Feng Y, Zhao CS, Cao SH*, Cai SH, Sun HJ, Chen Z, 2018. The electrochemical oxidation of hydroquinone and catechol through polyaniline and poly(aspartic acid) thin films: A comparative study. AIP Advances, 8(9):095007.
[43] Tan CH, Huang YQ*, Feng JH, Li ZS, Cai SH*, 2018. Freshness assessment of intact fish via 2D 1H J-resolved NMR spectroscopy combined with pattern recognition methods. Sensors and Actuators B: Chemical, 255: 348-356.
[44] Zhang XP, Jiang WL, Cao SH*, Sun HJ, You XQ, Cai SH, Wang JL, Zhao CS, Wang X, Chen Z*, Sun SG, 2018. NMR spectroelectrochemistry in studies of hydroquinone oxidation by polyaniline thin films. Electrochimica Acta, 273:300-306.
[45] Ma LC, Cai CB, Yang HY, Cai SH, Qian JC, Xiao LZ, Zhong K*, Chen Z*, 2018. Motion-tolerant diffusion mapping based on single-shot overlapping-echo detachment (OLED) planar imaging. Magnetic Resonance in Medicine, 80(1):200-210.
[46] Wang KY, Huang YQ*, Smith PES, Zhang ZY, Cai SH, Chen Z*, 2018. Single-scan high-resolution 2-D J-resolved spectroscopy in inhomogeneous magnetic fields. IEEE Transactions on Biomedical Engineering, 65(2):440-448.
[47] Liu Y, Lv XL, Liu H, Zhou ZJ, Huang JP, Lei SL, Cai SH, Chen Z, Guo YL, Chen ZW*, Zhou X, Nie LM*, 2018. Porous gold nanocluster-decorated manganese monoxide nanocomposites for microenvironment-activatable MR/photoacoustic/CT tumor imaging. Nanoscale, 10:3631-3638.
[48] Chen L, Xu X, Zeng HF, Chan KWY, Yadav N, Cai SH, Schunke KJ, Faraday N, vanZijl PCM, Xu JD*, 2018. Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse (VDMP) MRI. Magnetic resonance in medicine, 80(4):1568-1576.
[49] Cai CB, Wang C, Zeng YQ, Cai SH, Liang D, Wu YW, Chen Z*, Ding XH*, Zhong JH, 2018. Single-shot T2 mapping using overlapping-echo detachment planar imaging and a deep convolutional neural network. Magnetic resonance in medicine, 80(5):2202-2214.
[50] 2018年以前的略
发明专利
[1] Cai SH, Guo CL, Cai CB, Wu J. Method and system for reconstruction of CEST contrast image. US11587270B2B2. 授权日2023.2.21. (美国发明专利)
[2] Cai SH, Chen H, Chen Z. Method for longitudinal relaxation time measurement in inhomogeneous fields. US11047943B2. 授权日2021.6.29. (美国发明专利)
[3] 蔡淑惠，向鹏程，蔡聪波，王杰超，陈忠. 一种时空编码磁共振成像超分辨率重建方法及系统. ZL202110141998.7. 授权日2022.8.12.
[4] 蔡聪波，张晓娟，蔡淑惠，陈忠. 一种T2定量图像成像方法及系统. ZL201911069801.2. 授权日2022.8.12.
[5] 吴方圆，蔡聪波，蔡淑惠，王璐. 一种动态对比增强核磁共振图像的重建方法及重建系统. ZL202110419657.1. 授权日2022.7.29.
[6] 蔡淑惠，吴健，蔡聪波. 一种磁共振多参数同时定量成像方法及系统. ZL201911076119.6.授权日2022.5.13.
[7] 蔡淑惠，何雨泽，蔡聪波，杨奇志，欧阳斌宇. 一种磁共振T2定量成像方法及系统. ZL202110215919.2. 授权日2022.2.22.
[8] 蔡淑惠，郭晨露，蔡聪波，吴健. 一种化学交换饱和转移对比图像的重建方法及系统. ZL201911173109.4. 授权日2021.7.30.
[9] 蔡淑惠，练旭东，蔡聪波，吴健. 一种体素内不相干运动磁共振成像参数重建方法及系统. ZL201911148171.8. 授权日2021.4.6.
[10] 蔡淑惠，张俊，蔡聪波，廖璞，曾坤. 一种基于残差网络的单扫描磁共振定量T2成像重建方法. 201711287890.9. 授权日2020.2.18.
[11] 蔡聪波，王超，丁兴号，蔡淑惠，陈忠. 基于残差网络重建的单扫描定量磁共振T2*成像方法. ZL201810208422.6. 授权日2020.2.14.
[12] 蔡淑惠，罗瑶，张俊，蔡聪波. 基于分段激发的多回波多层时空编码磁共振成像方法. 201711494370.5. 授权日2020.1.14.
[13] 蔡淑惠，陈浩，陈忠. 一种在不均匀磁场下测量质子纵向弛豫时间的方法. ZL201710222672.0. 授权日2020.1.14.
[14] 蔡聪波，马崚嶒，陈忠，蔡淑惠，丁兴号. 基于重叠回波的单扫描同步磁共振扩散及T2成像方法. ZL201810765276.7. 授权日2020.1.14.
[15] 蔡淑惠，廖璞，蔡聪波，张俊，曾坤. 不均匀磁场下回波平面成像无参考扫描图像畸变矫正方法. ZL201711396029.6. 授权日2019.8.16.
[16] 黄玉清，陈忠，蔡淑惠，陈帅. 一种获得高分辨二维J分解谱的方法. ZL201610397699.9. 授权日2018.6.29.
[17] 陈忠，詹昊霖，叶奇淼，杨健，李弘，黄玉清，蔡淑惠. 一种抵抗不均匀磁场的超快速核磁共振二维J谱方法. ZL201710153235.8. 授权日2018.5.18.
[18] 蔡淑惠，张婷，蔡聪波，李敬，陈林，黄建攀. 一种基于分段激发时空编码的多层超快速磁共振成像方法. ZL201510887987.8. 授权日2018.4.24.
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著作
[1] Lin YL, Huang YQ, Cai SH, Chen Z, 2013. Intermolecular zero quantum coherence in NMR spectroscopy. Annual Reports on NMR Spectroscopy, Academic Press, Vol. 78, Chapter 5.
[2] Chen Z*, Huang YQ, Lin YQ, Cai SH, 2011. Accurate measurements of small J coupling constants. Annual Reports on NMR Spectroscopy, Academic Press, Vol. 72, Chapter 4.
